ABSTRACT
Objective To evaluate the clinical efficacy and safety of Chaigan Jieyou decoction in treating Parkinson's disease depression (PDD).Methods Applying the method of simple random contrast,this research collects 70 patients who meet the study criteria and divide the patients into two groups of 35 peoples each:Chaigan Jieyou decoction group,which received treatment of Chaigan Jieyou decoction and fluoxetine group with treatment of fluoxetine.Treatment period was 2 months.Apply the HAMD-17 (Hamilton Depression Scale),Beck Depression Scale (Beck Depression Inventory,BDI),Parkinson's composite score (unified Parkinson disease rating scale,UPDRS) and TCM symptoms rating scale to evaluate the clinical efficacy before and after treatment.Resuits Compared the two groups by HAMD Score reduction rate,there is no statistical significance in the general efficacy rate (P ＞ 0.05);compared by the curative effect of TCM syndrome,Chaigan Jieyou decoction group is better than fluoxetine group (P ＜ 0.05).There is statistical significance in the differences of all the HAMD,BDI,UPDRS Ⅱ,UPDRS Ⅲ scores between the two groups after the treatment (P ＜ 0.01,P ＜ 0.05).Compared the treatment efficacy by the HAMD scores,Chaigan Jieyou decoction can alleviate the clinical symptoms of patients of varying degrees.Conclusions Chaigan Jieyou decoction can significantly relieve depression of PDD patients,and there is exact curative effect to the mild and moderate PDD patients,improving their quality of life to a certain extent.
ABSTRACT
Objective To investigate the effect of Chaigan Jieyou Decoction on hippocampal neurons and the expression of hippocampal brain-derived neurotrophic factor(BDNF)in rats of Parkinson’s disease with depression (PDD). Methods Twenty-four adult male SD rats were randomly divided into 4 groups, namely normal group, model group, Chaigan Jieyou Decoction group and Fluoxetine group, 6 rats in each group. Except for the normal group, the rats in the other groups were fed solitarily. After the establishment of PDD model, the model group, Chaigan Jieyou Decoction group and Fluoxetine group were given intragastric administration of distilled water 2.0 mL, Chaigan Jieyou Decoction 8 g·kg-1, Fluoxetine 1.8 mg·kg-1 for one day respectively, once a day. The treatment covered 21 continuous days. The hippocampal neuron damage and the expression of BDNF in hippocampal tissues were detected by Nissl’s staining and immunohistochemistry, respectively. Results Compared with the normal group, model group had obvious morphological damage of the hippocampal neurons, while Chaigan Jieyou Decoction and fluoxetine could relieve the damage, showing certain protection of hippocampal neurons. Compared with the normal group, BDNF positive staining area, integral optical density (IOD), and mean optical density(MOD) of the hippocampus in the model group were significantly decreased (P<0.01). Compared with the model group, BDNF positive staining area, integral optical density and mean optical density in Chaigan Jieyou Decoction group and fluoxetine group were significantly increased(P<0.05 or P<0.01). Conclusion Chaigan Jieyou Decoction has an effect on the relief of the damage of neurons and the increase of expression of BDNF in hippocampus of rats with PDD, which probably contributes to one of its therapeutic mechanisms.
ABSTRACT
Objective To build rat models and observe changes of behavior and monoamine of PDD. Methods The rats were injected with 6-OHDA and accepted CUMS for the establishment of PDD model , so as to assess its behavior changes and detect brain tissue monoamine contents by ELISA. Results Significant behavioral and monoamine abnormalities can be observed in model rats. Behavioral and monoamine improvement can be observed after treated with Chaigan Jieyou. Conclusion The PDD model can be established by 6-OHDA and CUMS. Chaigan Jieyou decoction may reach therapeutic purposes by increasing monoamine contents.